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The direct effect of GLP-1 on adipose tissue has been demonstrated in many studies

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In the preclinical literature it is described above all as a cytoprotective and pro-angiogenic compound, acting locally within damaged tissue

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Because GLP-2 acts through subepithelial myofibroblasts, which are the same cell population implicated in intestinal fibrogenesis, the risk-benefit profile of GLP-2 agonism may differ substantially between mucosal UC, inflammatory ileal CD, and stricturing or penetrating CD phenotypes, and this phenotypic stratification should be a required feature of future trial design

Over 40% of older adults have obesity