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Am J Clin Nutr 2001;73:209-218
NICE guidance (NG28) supports their use in type 2 diabetes when glycaemic control is inadequate with other therapies
Three-times-weekly dosing (often Monday, Wednesday, Friday) further reduces usage and extends supply to approximately 16 weeks at 2mg per dose
(2) the specific CI inhibitor IACS-010759 was recently reported to promote neurotoxicity, making this an unattractive agent for combination therapy in CRC given the neurotoxicity long-recognized with oxaliplatin treatment 51
Important context: While worsening heart failure events were meaningfully reduced, cardiovascular deaths were numerically higher in the tirzepatide group at 2.2% versus 1.4% in the placebo group
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