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For most people, yes B12 is water-soluble and well tolerated
Research with senescent rhesus monkeys (aged 20-27 years) showed that Epithalon administration decreased basal plasma levels of glucose and insulin while increasing basal nighttime melatonin levelsreversing age-associated endocrine dysfunction patterns
Lian LY (1998)
Doses of more than 4,000 international units (IU) per day every day may lead to this toxicity, and you shouldn't do this unless you are under a doctor's guidance and supervision to treat a health condition
