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However, Epithalon's promise comes with important caveats - most research conducted in Russia with limited Western validation, no FDA approval or large-scale international trials, long-term human safety data spanning years not decades, optimal dosing still based on Russian protocols rather than rigorous dose-finding studies, and mechanisms incompletely understood despite 40 years of research

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This solution is typically applied daily

One of the most frequently discussed concerns is related to skin whitening a desired outcome for many, but also a controversial one when pursued aggressively without clinical oversight

Supplementary Information Additional file 1: (download DOCX Supplemental table 1

This homeostatic behavior of Hcy is intriguing: It runs counter to the clinical observation that vitamin B 12 deficiency results in hyperhomocysteinemia