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218 Furthermore, in animal research, intermediate and heavy alcohol intakes were found to temporarily but dramatically suppress glymphatic function, potentially leading to brain cell damage, whereas light alcohol intake was shown to increase glymphatic clearance

this inhibition increases urinary bicarbonate loss, slightly elevates urine pH, and explains both a predisposition to calcium-phosphate nephrolithiasis and the rare idiosyncratic syndrome of acute myopia with secondary angle-closure glaucoma

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Amgen reports maridebart caftaglutide (Maritide) in their pipeline