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Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation

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Potential complications include: Leakage Bleeding Nutritional deficiencies Gastroesophageal reflux Internal hernia Need for revision surgery Meanwhile, obesity medications avoid surgical risks but introduce their own concerns

doi:10.1136/thx.2005.048512

These differences may also explain differences in gastrointestinal adverse reactions, such as nausea and vomiting, which are common with GLP-1RAs but typically diminish over time [127, 128]