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The pooled impact was still significant (SMD = 0.996, 95% CI: 0.8631.129)

Patients often consider MOTS-c when dealing with low energy, reduced metabolic flexibility, or difficulty maintaining body composition

Cagrilintide shows greater potency and a longer half-life (approximately 7 days) than earlier amylin analogs like Pramlintide, which is why its generating attention in the metabolic optimization space

The advantages of GLP-1 agonists include substantial clinical trial data supporting their efficacy and safety, FDA approval for weight management in certain populations, proven results with many users losing 15-20% or more of body weight, and effects on appetite that make caloric restriction feel natural

Mao AS, Mooney DJ