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doi:10.1042/bj2860383

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Limitations of the intramuscular application of the solution are individual intolerance to one or more components

A systematic review published in Nutritional Neuroscience found 13 eligible trials and reported that 200 to 450 milligrams per day appears safe and effective for supporting healthy sleep in adults, while a 2021 randomized, triple-blind, crossover study used 200 milligrams and found increased alpha brain-wave activity and lower salivary cortisol after an acute stress challenge

This meets the needs of various patients and clinical situations