Research involving Glutathione commonly investigates its interaction with: Cellular oxidative-stress pathways Reactive oxygen species (ROS)-related mechanisms Antioxidant-support pathways involving compounds such as Vitamin C and Vitamin E Cellular detoxification and antioxidant-support signaling Cellular-resilience and physiological-maintenance pathways Because of its broad antioxidant research profile, Glutathione is frequently investigated in oxidative-stress, metabolic-support, healthy-aging, and physiological-resilience research models
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doi:10.1186/s12951-025-03248-7
In subsequent experiments, we confirmed that combining NBDHEX with PD-1 inhibitors resulted in potent anti-tumor effects, with good tolerance and safety observed in mice
Note also that GSH inhibits both GCL and GS, so it is not clear by inspection of the diagram what the effect of raising the activities of GCL and GPX will be
