Study SnapshotStudy TypeSystematic review and meta-analysis, PROSPERO-registered, exploratoryPopulation2,949 adults with multiple sclerosis pooled from 25 studies (49 articles were eligible for review)InterventionNabiximols, a THC/CBD oromucosal spray already approved as add-on therapy for MS spasticityComparatorPlacebo or standard care across the pooled randomized and non-randomized studiesPrimary Outcomes AssessedBladder function, sleep disruption, spasm quality, and gait/timed walkSecondary OutcomeSubject Global Impression of Change (SGIC) at one monthDatabases SearchedWeb of Science, MEDLINE via PubMed, Cochrane CENTRAL, and Embase, searched September 10, 2025Main FindingSignificant improvement in spasm quality, bladder function, sleep disruption, and timed walk
The % recovery and %CV of the analyte are 67.51%, and 2.77%
Bupropion (brand names include Wellbutrin and Zyban ) is commonly prescribed for depression and seasonal affective disorder
The recommended starting dose is 2.5 mg (0.25 mL), once weekly
Could it be that B12 was feeding budding tumors or something
Direct evidence is limited