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When comparing the global mutagenesis profile, the effects on exendin-4 were similar to those on GLP-1, with a strong positive correlation observed for the mutagenesis data for both affinity and cAMP production, albeit that the effect on cAMP signalling was generally smaller for exendin-4 (Figs

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Diabetologia 59:13721375 Liang Y, Osborne MC, Monia BP et al (2004) Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db / db mice