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20% of patients with NASH develop cirrhosis and have a high risk of hepatocarcinoma

Independent product testing is another problem: in several rounds of third-party assays, more berberine products have failed their label claims than passed, so the dose in the bottle is often not the 9001,500 mg used in trials

For a disulfide-containing synthetic peptide, a stronger analytical package may require orthogonal identity and purity methods, evidence supporting disulfide configuration, impurity profiling, assay or net peptide content, water and counterion determination, residual-solvent testing, and stability-indicating methods

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Liu, J., Huan, Y., Li, C., Liu, M., and Shen, Z