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There is mounting evidence that elevated plasma homocysteine (and therefore decreased serum methionine) contributes to congenital neural tube defects
2016;5:F1000 Faculty Rev-738
Chiu CK et al., J Neurol Sci 2011 High-dose methylcobalamin in ALS
[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed
The inclusion and exclusion criteria were defined in direct accordance with the PICOS framework
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