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Additional mice (n = 3/group) were administered with MEDI4166 at 10 mg/kg or Ab#2.1_EX4 at 10 or 30 mg/kg to determine human Fc and GLP-1R active compound concentrations by taking blood samples at the following times post-dosing: 2 h, 4 h, 8 h, 1, 3, 7, 14 and 21 days

One phase 3 clinical trial found that survodutide led to an average 12% to 18.7% body weight reduction , depending on dose, in adults with obesity and without diabetes after 76 weeks compared to 5% in the placebo group

A pending submission is not an approval, and cagrilintide may not be prescribed, dispensed, or sold for human use

The researchers have speculated that these effects are primarily due to stimulation of muscle regeneration via the activation of satellite cells by IGF-I

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