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Expanded structural studies using X-ray crystallography or cryo-EM (as outlined in Measurement 3) could provide atomic-level insights into species-specific differences, complemented by advanced molecular dynamics simulations to refine binding site predictions

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A recent systematic review (87) included eight randomized double-blind controlled trials using exogenous melatonin as an augmentation strategy in major depression, bipolar disorder or seasonal affective disorder in comparison with placebo