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In this trial, once-weekly cagrilintide-semaglutide for 68 weeks in adults with overweight or obesity was highly effective and led to substantial and clinically meaningful weight loss, the authors concluded

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Initially developed for managing type 2 diabetes, semaglutide has since been approved for weight loss and is now widely prescribed for both conditions

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Improved treatment satisfaction in patients with type 2 diabetes treated with once-weekly semaglutide in the SUSTAIN trials

These shifts are rarely dramatic enough to prompt a doctor's visit but they are consistent, and they are physiological