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Slower gastric emptying can blunt sharp glucose spikes after large carbohydrate loads

The combination carries no red flags in current pharmacologic evidence, and standard monitoring is sufficient to catch the rare unexpected hepatic signal early

Many patients report that once-weekly shots help them improve insulin sensitivity, feel fuller, and avoid the eating habits that led to their weight gain

Cell culture Caco-2 cells, a human colorectal carcinoma-derived epithelial cell line, were cultivated in Dulbeccos modified Eagles medium (DMEM)/F12 (Gibco) containing 10% fetal bovine serum (FBS) in a humidified incubator at 37 C, 5% CO 2

In clinical trials, the most common observations were gastrointestinal effects: nausea (44.2% vs 17.4% placebo in STEP 1), diarrhea (30.0%), vomiting (24.8%), and constipation (24.2%)

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