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Thus, in mice, significant antihyperglycaemic effects of DPP-4 inhibition are still apparent in animals lacking the GLP-1 receptor (43), while in clinical studies, GLP-1 receptor antagonism (using exendin 9-39) eliminates only approximately half of the glucose-lowering effect in patients with T2DM treated with DPP-4 inhibitors (44, 45)
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& Jitrapakdee, S
Cerebrospinal fluid insulin levels increase during intravenous insulin infusions in man
General stability and storage guidance for laboratory materials
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