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8 weeks) in C57BL/6 produces pericentral HSC activation, collagen I/III deposition (Sirius Red staining), and biochemical hepatitis (ALT, AST elevation)

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Because collagen holds together skin, cartilage, and other body structures together, insufficient glycine synthesis is associated with weak muscles and inadequate amounts of protein for maintaining homeostasisclinical studies show that lower plasma glycine levels correlate with lower metabolic capacity

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4E) and DMF treatment increases both NRF2 association and active histone codes at the CBS gene ARE motif (Fig