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Any combined use is based on theoretical pharmacology and individual drug studies rather than robust clinical evidence, making it an investigational approach

10.1016/j.job.2020.01.009 Radomska-Leniewska DM, Osiecka-Iwan A, Hyc A, Gd A, Dbrowska AM, Skopiski P: Therapeutic potential of curcumin in eye diseases

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This paper established NNMT as a legitimate research target for adipose biology specifically and triggered the broader small-molecule NNMT inhibitor research that includes 5-Amino-1MQ