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Commonly suggested biomedical hypotheses to explain PAIS (such as in long COVID/PASC, ME/CFS) are chronic stimulation of the immune system by a persistent infection or persistent unviable pathogen structures

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These are typically transient but can be significant for some patients

Sridhar V, Gaud R, Bajaj A, Wairkar S

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Redox imbalance stress in diabetes mellitus: role of the polyol pathway