MOTS-c is generally considered better for anti-aging purposes because it directly targets mitochondrial function and metabolic decline, both of which are central to the aging process
A phase-3 study was conducted to evaluate the safety and efficacy of VM202 in DPN
Anecdotal evidence from athletic and biohacking communities provides supplementary support
doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date
Too specific, reduces the risk of any undesirable hormonal swings
This physiological mechanism, which is useful for the post-translational modification of multiple proteins and for the regulation of signal and metabolic pathways, can turn harmful in case of oxidative stress, with the above-mentioned mitochondrial damage