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Ca 2+ overload activates calpain, a cysteine protease that degrades the cytoskeleton [91]
Current notable studies focus on its potential in treating infected or injured eyes, such as cases involving Pseudomonas aeruginosa -induced keratitis, and the facilitation of corneal wound healing [5, 6]
In research, this property is studied in cachexia models (muscle loss related to cancer, HIV, aging) where restoring a positive energy balance is a therapeutic goal (Pirrello et al., 2012)
Eur Heart J 1984;5(Abstr Suppl 1):138
doi: 10.12659/MSM.892081 83 CaeteFVelaECalafatMPieraJMaosaMDomnechE
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