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Insulin resistance is also responsible for fatigue, brain fog, skin tags, skin darkening, and more

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GLP-1RAs have been shown to reduce the activation of nuclear factor-kappa B (NF-B), a key regulator of inflammatory responses, thereby decreasing the production of pro-inflammatory cytokines such as TNF-, IL-6, and IL-1

Knight also avoids prescribing sermorelin to women with active malignancy or poorly controlled diabetes, since both involve growth-related or metabolic pathways that can be influenced by IGF-1

In individuals with Type 2 Diabetes (T2D), there is an observed increase in Gram-negative Enterobacteriaceae and a concurrent decrease in acetic acid-producing bacteria, such as Bifidobacteria