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Peak nausea usually occurs during the first 2-4 weeks and gradually improves as tolerance builds
10.3109/08037059209077499 54 LiuS.ZhangR.ZhangL.YangA.GuoY.JiangL.et al (2024)
Hunger increases, fullness becomes less reliable, and metabolic adaptation makes maintenance difficult
doi: 10.1016/j.cmet.2018.03.001 Wilding JPH, Batterham RL, Calanna S, et al
95 A 68-week phase III trial assessed the efficacy and safety of daily oral semaglutide 50 mg combined with moderate-intensity lifestyle interventions versus placebo in a cohort of obese individuals without T2DM