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Hemorrhoids and fissures share overlapping pathology, but extrapolating from fissure data to hemorrhoids is mechanistically plausible, not clinically validated

Additionally, a meta-analysis of 46 randomized trials, including 171,244 participants, found that supplemental vitamin E, singly or in combination with other antioxidants, did not significantly alter the risk of all-cause mortality (126)

Ricaurte GA, Schuster CR, Seiden LS (1980)

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