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Entomol Exp Appl 142(1):116
doi: 10.1007/s00213-011-2520-0 91 ReganSLWilliamsMTVorheesCV
A study demonstrated that the deletion of SIRT1 in hepatocytes leads to increase in PGC-1 acetylation levels disrupted PPAR- signaling followed by a decrease in fatty acid -oxidation, hepatic steatosis, liver inflammation, and ER stress 55,59
Toutefois, seule, elle ninduit pas de perte de poids significative : ses effets sont surtout observs en complment dune activit physique rgulire et dune alimentation quilibre
Tirzepatide was more efficacious in reducing body weight
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