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[9] That recommendation applies equally to sermorelin as a GH secretagogue

Complementary modeling studies suggest that GLP-1 RAs such as semaglutide and tirzepatide may disrupt the typical feedback loop in which weight loss leads to compensatory increases in appetite, potentially extending the period of reduction before plateauing occurs

In studies comparing insulin administration with once weekly GLP-1RA, including albiglutide and exenatide, local site reactions were more common with GLP-1RA (~10%), compared with 15% with insulin (95)

Rasquin, and C

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However, the absence of a direct drug interaction does not mean the combination is without considerations