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3B), siTCF7L2 significantly reduced TCF7L2 mRNA levels compared to control, and such reduction of TCF7L2 led to the significant down-regulation of GLP-1 receptor mRNA expression level, respectively (p = 0.0005, p = 0.0024)
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coli 15,017, respectively, were analyzed
This opposing effect creates unpredictability in glucose control and raises the risk of hypoglycemia or metabolic destabilization if doses are not carefully titrated and monitored
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