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Who Needs Extra Caution and When to Reassess Dosing Patients with baseline systolic blood pressure under 120 mmHg, those on three or more antihypertensive agents, or those with kidney disease or heart failure should discuss GLP-1 use more thoroughly with their provider before starting
Patients with existing heart or kidney disease may benefit from starting SGLT-2 inhibitors therapy, while those with a higher risk of developing these conditions, such as obese patients and those with no cardiogenic stroke, may benefit more from GLP-1 RAs
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Figure 4 shows that discontinuation rates for SGLT2 inhibitors differed little between subgroups of patients by status of ASCVD, chronic kidney disease and heart failure, although some of the differences were statistically significant
A.RiahiF.HajmohammadiM.TiznobeykZ.MousavinejadM
Long-term data is still emerging, but one study published in the May issue of the Journal of Managed Care and Specialty Pharmacy (JMCP) identified that approximately two-thirds of patients treated with GLP-1 RAs for obesity experienced at least a 60-day gap in treatment within the first year and just over one-quarter of patients remained at least 80% adherent to therapy
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