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J Cell Physiol 217(2):377387 Liangpunsakul S, Chalasani N (2005) Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III)
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Psychoneuroendocrinology 65, 5466
For most of these agents, therefore, by the time you discount those future events back in terms of quality-adjusted life-years, and also in terms of the economic value of those costs, it's challenging for new products to be cost-effective
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