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Preliminary Phase I trials have shown a differentiating clinical profile for ECC5004, with good tolerability and encouraging glucose and body weight reduction across the dose levels tested compared to placebo

Although feeling cold is not a documented side effect of Mounjaro specifically, there are several indirect mechanisms through which weight loss medicationsand the weight loss they producemay influence temperature perception and thermoregulation

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These include enrichment of mesenchymal-like states, increased PUFA-containing phospholipids, and elevated basal ROS levels (92)