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In the structures of human and yeast GS, two alanine residues form van der Waals contacts with the glycine moiety of glutathione (Polekhina et al., 1999

New England Journal of Medicine: Retatrutide Phase 2 trial results - The landmark study establishing retatrutide efficacy and safety across multiple dose groups New England Journal of Medicine: STEP 1 semaglutide trial results - The pivotal trial demonstrating semaglutide 2.4 mg weight loss efficacy ClinicalTrials.gov: Retatrutide TRIUMPH program - Current status and details of all ongoing Phase 3 retatrutide trials FDA prescribing information for Wegovy (semaglutide 2.4 mg) - Complete approved labeling including dosing, safety, and clinical data New England Journal of Medicine: SELECT cardiovascular outcomes trial - The trial demonstrating semaglutide 20% reduction in major cardiovascular events These primary sources should be the foundation for any serious evaluation of either compound

Key takeaways GLP-1 medications offer real benefits for managing diabetes and obesity, though some users may have noticed their hair getting thinner

The primary contraindication relates to a specific, rare form of thyroid cancer (Medullary Thyroid Cancer)

Thats not because the drug didnt work or was found to be unsafe, Sikiric said, but because the people at GSK were wedded to their own projects

these are not the best side effects Ive ever seen but also not the worst