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Long-term selenium supplementation in HaCaT cells: importance of chemical form for antagonist (protective versus toxic) activities

Cytokine Modulation Pro-inflammatory cytokines like TNF-alpha, IL-6, and IL-1beta drive the inflammatory cascade that causes pain, swelling, and tissue damage

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Accumulating findings further suggest that intestinal inflammation may trigger misfolding of -synuclein within enteric neurons, enabling its propagation to the brainstem via vagal pathways and providing a mechanistic link between gut pathology and dopaminergic neurodegeneration