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For example, metformin-treated T2DM patients with elevated levels of Bacteroides fragilis in the gastrointestinal tract, whose metabolite glycoursodeoxycholic acid (GUDCA) is involved in inhibiting FXR signaling (Sun et al., 2018)

They produce weaker vasodilators such as peroxynitrite NO2 and NO3, which may interfere with endothelium-dependent vasodilators

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Pay attention to any mentions of side effects or how long it took to see results