glp 1 for cholesterol levels Anti-atherosclerotic effects of the glucagon-like peptide-1 (GLP-1) based therapies in patients with type 2 Diabetes Mellitus: A meta-analysis Nutritional Approaches to Enhance GLP-1

Fast forward to today and its a dramatically different story

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A noticeable side effect of GLP-1 analogs in type 2 diabetes treatment is weight loss

Across the SLD spectrum, GLP-1 RAs demonstrated modest but directionally consistent improvements in liver enzyme profiles (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]), with 4 of the 7 ALT outcome estimates showing significant reductions, and 4 of the 9 AST outcome estimates showing significant reductions

doi: 10.1016/j.mce.2017.04.008

This effect is mediated through its action on the brains appetite centers, promoting a sense of fullness and satisfaction after meals