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If left unchecked, insulin resistance often leads to the development of metabolic syndrome, type 2 diabetes, liver disease, and cardiac disease
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a drop in the AMP:ATP and ADP:ATP ratios indicates low energy availability and triggers AMPK activation
L., Sly, W
Tissue studies remain essential, but clinical translation will likely depend on plasma panels combined with imaging, natriuretic peptides, troponin, renal function, and machine-learning models that are externally validated (13)
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