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The differences observed can be attributed to several factors inherent to real-world studies as compared to RCTs, and future work is needed to further characterize patient profiles most likely to benefit from GLP-1s with findings from both structured and unstructured clinical data modalities

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For patients with Amyotrophic Lateral Sclerosis, glutathione has been shown to mitigate muscle weakness and improve overall quality of life

Comparative data from tirzepatide studies in type 2 diabetes (SURPASS trials) similarly show low rates of dizziness as a primary complaint

These findings prompted us to hypothesise that GLP-1R may play a central role as the primary mediator of triagonist-induced responses in pancreatic islets

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