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A molecule that is not what its label claims is not simply ineffective, it is a genuine safety concern, because you cannot know what you are actually putting into your body

Chemical Engineering Journal, 473 , 145190

For example, a co-crystallization strategy reveals that ML162 effectively targets all catalytic tetrad residues in GPX4 by interacting with Sec46, Gln81, Trp136, and Asn137, thereby completely obstructing the active site [218]

Where human data exist, they are limited and methodologically weak, often lacking proper controls or large sample sizes