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Adverse Reactions/Side Effects Vitamin B12 is known to be non-toxic even in high doses

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Importantly, animals were singly housed to eliminate the exchange and cross-contamination of intestinal microbiomes, a factor that potentially biases studies with group-housed animals by minimizing microbiome variations for co-housed animals within a cohort

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The US-FDA initially approved the drug in 1942 (7)

However, intramuscular administration isnt necessary