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In contrast to unbiased GLP-1 receptor therapies, ecnoglutide selectively activates cyclic adenosine monophosphate (cAMP) signaling pathways while minimizing -arrestin recruitment

Pharmacological treatment modalities such as glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors have become increasingly accepted as viable antidiabetic treatment options due to their safety and favorable cardiovascular profiles [9, 10]

Drugs originally designed to treat diabetes have become a popular tool for weight loss, with millions of Americans now using GLP-1 medications to shed pounds

Lopes, Pluronic triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview

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J Biol Chem (2012) 287:4016172