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Across different modalitiesincluding caloric restriction, exercise-based interventions, pharmacological agents, and bariatric surgeryweight reduction has been shown to result in bone loss, reduced BMD, and compromised bone quality

Gilbert, Rosenthal, March 2024

Both early evidence and anecdotal reports point to a range of potential benefits

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The Cardiac-Kidney-Liver (CKL) syndrome: the real entity of type 2 diabetes mellitus

[56] demonstrated that mice injected with MPTP but also receiving -HB exhibited a smaller reduction in substantia nigra neurons, indicating that -HB can attenuate the neurotoxic effects of MPTP on dopaminergic cell bodies