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[insert before and after photos] Weeks 1 to 4: Initiation Phase Starting Dose: Treatment typically begins at 0.25 mg once weekly

J., Sozer, N., Koehorst, M., Holst, J

Kom et al., Diabetes Care 2025: commentary describing GLP-1 and GLP-1/GIP multidose-pen fractional titration below the FDA-approved starting dose for GI tolerability, drug transitions, or cost

The peptide is now in an aqueous solution where it is biologically active but also far more susceptible to degradation

Some practitioners experiment with splitting the 15 mg weekly dose into two injections of 7.5 mg given 3-4 days apart

For long-term maintenance: Traditional methods build lasting habits and improve overall health