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Reflecting this difficulty Novartis and Probiodrug had to abandon some of their early drug candidates because they proved unsafe and too toxic (Cordes)

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Its not clear how many supplements were combined in this research (multiple micronutrients (MMN), vitacap or seidivid were listed)

On average, people using tirzepatide in studies lost around 510% of their body weight during the early months, depending on the dose and lifestyle factors such as diet and physical activity

Some important health and lifestyle details such as smoking or sun exposure were not available, which means other factors could have influenced the results