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[Content Brief] [3]

This work now shows a direct line from biochemical and biophysical understanding of protein interactions to an inhibitor, says Kritzer, who was not involved in the research

Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

The images were captured using a Canon PowerShot A640 digital camera

Methods Mice Small and large intestinal tissues used in the ex vivo organ culture system were dissected from sacrificed C57BL/6J (B6) mice