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Add GIP receptor activation, as Tirzepatide does, and you layer in improved insulin sensitivity, enhanced fat metabolism, and what appears to be reduced GI side effects compared to GLP-1-only approaches

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Activation of these receptors can sometimes cause a slight increase in heart rate

PubMed 38608696

Generation and identification of reactive metabolites by electrochemistry and immobilized enzymes coupled on-line to liquid chromatography/mass spectrometry

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