An oral melanotic macule found on the lip is sometimes called a labial melanotic macule
The mechanisms are mainly focused on appetite restriction and food intake reduction by turning up the satiation signals and turning down the hunger signals in the arcuate nucleus of the hypothalamus (16, 17)
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SLC7A11 inhibition results in GSH depletion, which downregulates GPX4 levels, thereby promoting cellular/subcellular membrane damage caused by LPOs [28]