JAMA Intern Med 182 , 513519 (2022)
A meta-analysis of seven SURPASS clinical trials in participants with T2DM showed the hazard ratios comparing tirzepatide versus controls of 0.80 (95% CI, 0.57 1.11) for 4-MACE, 0.90 (95% CI, 0.50 1.61) for cardiovascular death, and 0.80 (95% CI, 0.51 1.25) for all-cause mortality (264)
Gamma-glutamyltransferase: A predictive biomarker of cellular antioxidant inadequacy and disease risk
Important safety questions include product purity, dose accuracy, drug interactions, liver and kidney considerations, blood sugar changes, cardiovascular risk, pregnancy or breastfeeding status, and long-term exposure
Berberine activates AMP-activated protein kinase (AMPK), influencing glucose metabolism and lipid profiles in metabolic syndrome populations
It also explores strategies for restoring gut microbiota balance and functionality by promoting beneficial microbes, increasing the production of beneficial metabolites, clearing toxic metabolites, and reducing the proportion of proinflammatory microbes