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Chemical agents targeting GLSs have been studied, and CB-839, 968, and BPTES have been found to exhibit tumor-specific antiproliferative effects 199
However, indirect factors such as reduced dietary intake from decreased appetite, altered gastric emptying, and concurrent use of metformin may increase the risk of B12 deficiency in some patients
These microorganisms are adept at transforming a variety of toxins, including hydrocarbons, heavy metals, and organic pollutants, into less harmful substances (Adnane et al., 2024
However, phentermine monotherapy remains indicated only for relatively brief use (several weeks up to 12 weeks) and is discontinued thereafter to mitigate tolerance and side effects
Mice in the Ischemia-Reperfusion group displayed erratic and limited movement patterns, consistent with impaired motor and exploratory behavior
Pyridoxine can serve as a buffer, allowing faster dose escalation while keeping nausea within tolerable limits
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