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Puglisi S, Rossini A, Poli R, Dughera F, Pia A, Terzolo M, et al
Stimulus-secretion coupling of arginine-induced insulin release
The mechanisms underlying an augmented GLP-1 response to intraduodenal glucose after Met (60 min) and Met (30 min) remain uncertain, but may reflect an effect of metformin on inhibiting glucose absorption in the upper small intestine, with consequent increased exposure of L cells to glucose more distally in the gut
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